Virulence: An Infectious Card Game Review

Virulence board game

Have you ever imagined what life as a virus might be like ? Always struggling for survival and searching for healthy cells to infect, in order to replicate yourself, become stronger and ultimately dominate an organism. I don’t know if I could handle that much anxiety, if you ask me. “Virulence” is a card game designed by John Coveyou that tries to put you in the shoes of malicious viruses, trying to infect host cells and replicate their viral components.

Virulence can be played by 2 to 5 players, with the 2-player game being a variant and it lasts about 15-20 minutes. Its only components are cards, plus 6 six-sided dice. The goal of the game is to score as many points possible by replicating the viral components of viruses namely: Icosahedral and Helical structures, Spherical Envelopes and Genomes.

Each player starts out with the same Starting Virus cards, each with virulence 1 – 6 and one Reassortment card.

Virulence, starting virus cards

 Virulence, starting virus cards

There are 4 bonus cards that give extra points to the player that completes first a set of Helical or Icosahedral structures. During game setup these are shuffled and one is randomly removed. The rest are placed near the playing area face down and the top card is flipped face up.

Bonus Cards

The deck of Viral Component cards is shuffled and placed in the middle of the table face down. Each round of the game, the following happens:

  1.  A number of cards are revealed from the top of the Viral Component deck, equal to the number of players.
  2. Each player chooses secretly a virus card, then all players simultaneously flip these cards to reveal their virulence.
  3. Starting from the player with the highest virulence, each player picks a card from the available Viral Component cards to add to his collection. If the same virus card is chosen by more than one player, two dice are rolled by each tying player to determine who will pick a card first. Possible cards to pick are:
  • Icosahedral. A total of four cards is required to complete a set. Points are awarded even if you don’t complete a set. The more cards the higher points are awarded.
  • Helical. A total of six is required to complete a set. Points are awarded even if you don’t complete a set. The more cards the higher points are awarded.
  • Spherical Envelope. The player who, at the end of the game has the more cards, receives 12 points, the second best player receives 6 points and the last -6 points.
  • Genome. These cards are worth a number of points written on them.
  • Vaccine. These are worth negative points written on the cards.
  • Wild cards: Icosahedral / Helical. Can be added to a set acting as either of the two.
  • Mutated Virus Cards. These are extra virus cards with values 1,7,8,9 that can be added to the hand of players replacing an existing virus card.
  • Increased Virulence. These cards give a bonus to the dice rolled when two or more players choose the same virus card.
Virulence sample cards
Virulence sample cards

When all virus cards have been played except the Reassortment card, they are returned to the player’s hand on the next round. The Reassortment card can be used to take back all virus cards from the player’s discard pile at any given time by sacrificing the round (You will not pick a Viral Component card that round).

The game continues until there are not enough Viral Component cards to be flipped face up from the Viral Component deck. Then players calculate their scores and the player with the most points wins!

Now let’s see how the game scores in our usual scoring categories:


Cards are the sole component of the game along with six dice. They are made of high quality glossy cardboard and their artwork represents the theme of the game in the most appealing way. The Viral Component cards show exactly the components they represent and create immersion to the theme of the game. The artistic design of cards is impressive, using bright colors and cool representations of the virus components. Moreover, on the cards there is a reminder of how they are scored so players won’t need to remember that information by heart. It would be great if the virus cards had different artwork according to their value, e.g. the card with value 1 could depict a small virus and the card with number 8 a very big and malicious one. The dice are pretty standard with the only difference from regular six-sided dice being the side with the value six, where a virus symbol is depicted.  

Virulence components

With the quantity of card games in the market the last few years, making a game that is original and truly interesting is not an easy task at all. Virulence has very simple gameplay with a few but important tweaks that really make a difference. The blind bidding mechanism is always interesting and fun and creates unpredictable situations. Players must manage their hands of virus cards in a smart way, being careful not to waste high virulence virus cards for not very important Viral Component cards. Of course, the importance of cards is relative and depends on what cards each player focuses on collecting.

An aspect of the game I really liked is the deck building mechanic and the way it is being implemented in the game. You can’t directly choose the cards to add to your virus card deck but instead you must bid for them. Moreover you can’t directly choose the cards that will be replaced by the mutated virus cards because you can only replace cards that reside on your personal discard pile. These facts add to the strategic depth of the game, forcing players to make plans and spend more thought to their bets and choices of cards. The inclusion of mutated virus cards with value 1 to the deck of cards is also a very smart design touch to the game, as this is a card that will weaken the virus card deck of the player that will be forced to choose it if he is the last one to make a pick.

Virulence mutated cards
Mutated cards

Luck plays its role in the game, as virus card ties, where the dice are used, are pretty common. Even so, the game still gives you the opportunity to improve your chances of winning ties, through the Increased Virulence cards that add a bonus to each dice roll and also score some points at the end of the game. This way the element of luck becomes more controlled and less frustrating to players.

All the above aspects of the game, give a sense of control over your fate as a virus which really felt great and is something I always look for in a game. Moreover it is a rare case that such a simple game achieves that, which makes the designer’s work even more important.

Virulence can be played by two to five players, with the 2-player game being really a variant. Gameplay is equally good with three to five players, with the 2-player variant being well-thought, still a little less interesting than a game with more players.

All in all, attention in detail and a very well-balanced gameplay have stolen my heart in this game.   

Learning Curve

“Virulence” is a card game that really can be taught in 5 minutes even to non-gamer players. Its rules are super simple and details of how Viral Component cards are scored, appear on the cards. The 10-page rulebook explains everything in a sufficient way. I really liked a lot the inclusion in the last page of the science involved in the game and the way the game replicates this science in gameplay.   


This is clearly a thematic game, inspired by real science and aiming to stay as close as possible to its theme while retaining simplicity of rules. The science behind the game is explained on the last page of the rulebook together with an account of how the most important aspects of the game are tied with the science involved. Elements of the game that have a direct link to science involved are:

  • Players take on the role of viruses competing to invade a host cell. Virulence represents the strength of a virus. The stronger the virus (the higher the virulence) the sooner it gets to replicate its Viral Components. This is represented in the game by the player selecting from the available Viral Component cards.
  • Viral component cards represent the real most important parts of a virus. Icosaedral and Helical structures are the main structures that form the shell of a virus. Spherical Envelope in reality surrounds the main structures of some viruses giving it extra protection. Genomes are the Genetic Code that contains the information of how to create more of that kind of virus. Collecting viral component cards represents the way viruses are reproduced by the genetic code being read by the host cell, infected by the virus.

I found the implementation of the game in relation to the science involved pretty accurate although it focuses on the replication process and leaves us a bit in the dark about the process of infecting the host cell. The fact that we learn, through gameplay and through the explanations in the rulebook, how viruses work is much appreciated and is a fun way for kids to learn about this process. 


Though the game has very simple rules, it includes many design touches that ensure that you won’t be bored as usually happens in this kind of small-duration games. The secret bidding, the ability to improve your virus card deck and to reduce the element of luck, all present choices for players and opportunities to manipulate the game so that no game is the same. I would play again Virulence at any given time. 


The blind bidding mechanism is for certain one of the most fun aspects of the game and the one which will fuel many hilarious comments between players. Such comments will surely come up also when the last player to pick is forced to choose a vaccine or a mutated virus card with the value of 1. Dice rolling is also fun and Increased Virulence cards can make the overall result of handling ties unpredictable.  

Final Verdict

“Virulence: An Infectious Card Game” is a simple card game that surprised me in the most positive way. Though it can be taught within minutes, it presents solid gameplay with plenty of choices and a sense of control over the way the game progresses. Apart from choosing the Viral Component cards, you can also improve your hand of virus cards which will enable you to choose even better cards. The element of luck is present in the game through dice rolling but can be contained by choosing to pick Increased Virulence cards. The heart of the game lies on careful planning of how to play your virus cards in the most sufficient way. The artwork of the game stands out with its colorful design that stays close to the theme. This game presents an excellent way for kids to learn how a virus works while having a lot of fun. Its tight mechanisms make it a solid choice in the category of short-duration board games. The publisher of the game, Genius Games, focuses on games related to science and also publishes science textbooks. You can find more of their science-based board games here.

Recommended for:  non-gamers, kids and serious gamers, a game for all really

If you like this game, you can buy it from the link below along with other science games from Genius Games  :

Virulence: An Infectious Card Game" is a simple card game that surprised me in the most positive way. Though it can be taught within minutes, it presents solid gameplay with plenty of choices and a sense of control over the way the game progresses.
  • Easy rules
  • Teaches kids science while having fun
  • Impressive artwork on cards and gamebox
  • Challenging gameplay that gives control over many aspects of the game
  • Blind bidding = fun
  • Theme implementation could be slightly better
Components - 7
Gameplay - 9
Learning Curve - 10
Theme - 7
Replayability - 8
Player Interaction - 7
Written by
Maria is an avid board gamer, interested also in video games, movies and tennis. She is also an accomplished surveying engineer and a proud mum.

Have your say!

0 0

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Lost Password

Please enter your username or email address. You will receive a link to create a new password via email.